TFG Defects in TFG are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Oncoprotein
Chromosomal Location of Human Ortholog: 16|16 C1.1
Cellular Component:  endoplasmic reticulum exit site
Molecular Function:  identical protein binding; protein binding
Biological Process:  ER to Golgi vesicle-mediated transport
Reference #:  Q9Z1A1 (UniProtKB)
Alt. Names/Synonyms: AI173908; Tfg; TFG protein; Trk-fused; Trk-fused gene
Gene Symbols: Tfg
Molecular weight: 43,020 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene