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IFNG
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Belongs to the type II (or gamma) interferon family. Released primarily from activated T lymphocytes. Note: This description may include information from UniProtKB.
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| Protein type: Cytokine; Membrane protein, integral; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 10 D2|10 66.75 cM |
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Cellular Component:
external side of plasma membrane; extracellular region; extracellular space; perikaryon
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Molecular Function:
cytokine activity; protein binding; type II interferon receptor binding
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Biological Process:
adaptive immune response; antigen processing and presentation; apoptotic process; astrocyte activation; CD8-positive, alpha-beta T cell differentiation involved in immune response; cellular response to interleukin-18; cellular response to lipopolysaccharide; defense response to bacterium; defense response to Gram-positive bacterium; defense response to protozoan; defense response to virus; endoplasmic reticulum unfolded protein response; extrinsic apoptotic signaling pathway; humoral immune response; immune response; inflammatory cell apoptotic process; interleukin-12 production; macrophage activation involved in immune response; macrophage cytokine production; macrophage differentiation; microglial cell activation; negative regulation of amyloid-beta clearance; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of epithelial cell differentiation; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of glomerular mesangial cell proliferation; negative regulation of interleukin-17 production; negative regulation of myelination; negative regulation of osteoclast differentiation; negative regulation of smooth muscle cell proliferation; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; neuroinflammatory response; neutrophil apoptotic process; neutrophil chemotaxis; nitric oxide biosynthetic process; positive regulation by host of viral process; positive regulation of amyloid-beta formation; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of calcidiol 1-monooxygenase activity; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; positive regulation of cell adhesion; positive regulation of cell population proliferation; positive regulation of cellular respiration; positive regulation of chemokine production; positive regulation of core promoter binding; positive regulation of cytokine production; positive regulation of DNA-templated transcription; positive regulation of epithelial cell migration; positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; positive regulation of fructose 1,6-bisphosphate metabolic process; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-23 production; positive regulation of interleukin-6 production; positive regulation of iron ion import across plasma membrane; positive regulation of isotype switching to IgG isotypes; positive regulation of killing of cells of another organism; positive regulation of macrophage cytokine production; positive regulation of membrane protein ectodomain proteolysis; positive regulation of MHC class II biosynthetic process; positive regulation of neurogenesis; positive regulation of neuron death; positive regulation of neuron differentiation; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of nitrogen compound metabolic process; positive regulation of NMDA glutamate receptor activity; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of phagocytosis; positive regulation of protein deacetylation; positive regulation of protein import into nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of protein-containing complex assembly; positive regulation of signaling receptor activity; positive regulation of smooth muscle cell apoptotic process; positive regulation of synaptic transmission, cholinergic; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vitamin D biosynthetic process; receptor signaling pathway via JAK-STAT; regulation of defense response to virus by host; regulation of DNA-templated transcription; regulation of glial cell proliferation; regulation of hepatocyte proliferation; regulation of immune response; regulation of insulin secretion; regulation of neuronal action potential; regulation of the force of heart contraction; response to virus; sensory perception of mechanical stimulus; T cell proliferation; T cell receptor signaling pathway; type II interferon-mediated signaling pathway; type III interferon-mediated signaling pathway
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Reference #:
P01580
(UniProtKB)
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Alt. Names/Synonyms: gamma interferon; Ifg; IFN-g; IFN-gamma; Ifng; Interferon gamma; interferon, gamma
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Gene Symbols: Ifng
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Molecular weight:
17,907 Da
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Basal Isoelectric point:
8.72
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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