PUM3 Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component:  chromosome; endoplasmic reticulum; nucleolus; nucleoplasm
Molecular Function:  DNA binding; protein binding
Biological Process:  regulation of protein ADP-ribosylation
Reference #:  Q15397 (UniProtKB)
Alt. Names/Synonyms: HBV X-transactivated gene 5 protein; HBV XAg-transactivated protein 5; HLA-HA8; KIAA0020; MGC8749; Minor histocompatibility antigen HA-8; PEN; penguin homolog; protein 5 transactivated by hepatitis B virus X antigen (HBxAg); PUF6; PUM3; Pumilio domain-containing protein KIAA0020; Pumilio homolog 3; pumilio RNA binding family member 3; XTP5
Gene Symbols: PUM3
Molecular weight: 73,584 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
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PUM3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene