JAM-A Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. Belongs to the immunoglobulin superfamily. Expressed in endothelium, epithelium and leukocytes (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component:  bicellular tight junction; cell junction; cell-cell junction; cytoplasmic vesicle; integral component of membrane; plasma membrane; slit diaphragm
Molecular Function:  PDZ domain binding; protein binding; virus receptor activity
Biological Process:  actomyosin structure organization; bicellular tight junction assembly; cell adhesion; establishment of endothelial intestinal barrier; extracellular matrix organization; inflammatory response; intestinal absorption; leukocyte migration; negative regulation of GTPase activity; positive regulation of blood pressure; positive regulation of GTPase activity; protein localization to plasma membrane; regulation of actin cytoskeleton reorganization; regulation of cytokine production; regulation of membrane permeability; response to radiation; transforming growth factor beta receptor signaling pathway; viral entry into host cell
Reference #:  Q9Y624 (UniProtKB)
Alt. Names/Synonyms: CD321; F11 receptor; F11R; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; Junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; PAM-1; Platelet adhesion molecule 1; Platelet F11 receptor
Gene Symbols: F11R
Molecular weight: 32,583 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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