ITGA2 Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of human Ortholog: 5q11.2
Cellular Component:  axon terminus; basal part of cell; cell surface; external side of plasma membrane; focal adhesion; integrin alpha2-beta1 complex; integrin complex; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  amyloid-beta binding; collagen binding; collagen binding involved in cell-matrix adhesion; collagen receptor activity; heparan sulfate proteoglycan binding; integrin binding; laminin binding; metal ion binding; protein binding; protein heterodimerization activity; protein-containing complex binding; virus receptor activity
Biological Process:  animal organ morphogenesis; blood coagulation; cell adhesion; cell adhesion mediated by integrin; cell proliferation; cell-matrix adhesion; cell-substrate adhesion; cellular response to estradiol stimulus; cellular response to mechanical stimulus; collagen-activated signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; establishment of protein localization; extracellular matrix organization; female pregnancy; focal adhesion assembly; hepatocyte differentiation; hypotonic response; integrin-mediated signaling pathway; mammary gland development; mesodermal cell differentiation; positive regulation of alkaline phosphatase activity; positive regulation of cell adhesion; positive regulation of cell projection organization; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of DNA binding; positive regulation of epithelial cell migration; positive regulation of inflammatory response; positive regulation of leukocyte migration; positive regulation of phagocytosis, engulfment; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of translation; positive regulation of transmission of nerve impulse; response to amine; response to drug; response to hypoxia; response to L-ascorbic acid; response to muscle activity; response to parathyroid hormone; skin morphogenesis; substrate-dependent cell migration; viral entry into host cell
Disease: Bleeding Disorder, Platelet-type, 9
Reference #:  P17301 (UniProtKB)
Alt. Names/Synonyms: alpha 2 subunit of VLA-2 receptor; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; Integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); ITA2; ITGA2; platelet antigen Br; platelet glycoprotein GPIa; platelet glycoprotein Ia; Platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA-2 subunit alpha; VLAA2
Gene Symbols: ITGA2
Molecular weight: 129,296 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB