STARD13 GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of mouse Ortholog: 5|5 G3
Cellular Component:  cytoplasm; lipid droplet; membrane; mitochondrion
Molecular Function:  GTPase activator activity; lipid binding
Biological Process:  cell cycle; endothelial cell migration; endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of sprouting angiogenesis; signal transduction
Reference #:  Q923Q2 (UniProtKB)
Alt. Names/Synonyms: DLC; DLC2; GT650; MGC38133; OTTMUSP00000027436; serologically defined colon cancer antigen 13; serologically defined colon cancer antigen 28; STA13; StAR-related lipid transfer (START) domain containing 13; StAR-related lipid transfer protein 13; StARD13; START domain-containing protein 13
Gene Symbols: Stard13
Molecular weight: 125,060 Da
Basal Isoelectric point: 7.26  Predict pI for various phosphorylation states
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STARD13

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene