STARD13 GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of human Ortholog: 13q13.1-q13.2
Cellular Component:  cytosol; lipid droplet; mitochondrial membrane
Molecular Function:  GTPase activator activity; lipid binding; protein binding
Biological Process:  actin cytoskeleton organization; endothelial cell migration; endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q9Y3M8 (UniProtKB)
Alt. Names/Synonyms: 46H23.2; ARHGAP37; Deleted in liver cancer 2 protein; DLC-2; DLC2; FLJ37385; GT650; LINC00464; long intergenic non-protein coding RNA 464; Rho GTPase activating protein on chromosome 13q12; Rho GTPase-activating protein; STA13; StAR related lipid transfer domain containing 13; StAR-related lipid transfer (START) domain containing 13; StAR-related lipid transfer protein 13; STARD13; START domain containing 13; START domain-containing protein 13
Gene Symbols: STARD13
Molecular weight: 124,967 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
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STARD13

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein