STARD13
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Tumor suppressor |
Chromosomal Location of human Ortholog: 13q13.1-q13.2 |
Cellular Component:
cytosol; lipid droplet; mitochondrial membrane
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Molecular Function:
GTPase activator activity; lipid binding; protein binding
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Biological Process:
actin cytoskeleton organization; endothelial cell migration; endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction
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Reference #:
Q9Y3M8
(UniProtKB)
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Alt. Names/Synonyms: 46H23.2; ARHGAP37; Deleted in liver cancer 2 protein; DLC-2; DLC2; FLJ37385; GT650; LINC00464; long intergenic non-protein coding RNA 464; Rho GTPase activating protein on chromosome 13q12; Rho GTPase-activating protein; STA13; StAR related lipid transfer domain containing 13; StAR-related lipid transfer (START) domain containing 13; StAR-related lipid transfer protein 13; STARD13; START domain containing 13; START domain-containing protein 13
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Gene Symbols: STARD13
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Molecular weight:
124,967 Da
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Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
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