STARD13 GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 13q13.1-q13.2
Cellular Component:  cytosol; lipid droplet; mitochondrial membrane
Molecular Function:  GTPase activator activity; lipid binding; protein binding
Biological Process:  endothelial cell migration; endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q9Y3M8 (UniProtKB)
Alt. Names/Synonyms: 46H23.2; ARHGAP37; Deleted in liver cancer 2 protein; DLC-2; DLC2; FLJ37385; GT650; LINC00464; long intergenic non-protein coding RNA 464; Rho GTPase activating protein on chromosome 13q12; Rho GTPase-activating protein; STA13; StAR related lipid transfer domain containing 13; StAR-related lipid transfer (START) domain containing 13; StAR-related lipid transfer protein 13; STARD13; START domain containing 13; START domain-containing protein 13
Gene Symbols: STARD13
Molecular weight: 124,967 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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