FLOT1 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Belongs to the band 7/mec-2 family. Flotillin subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 17|17 B1
Cellular Component:  basolateral plasma membrane; caveola; cell-cell adherens junction; cell-cell contact zone; cell-cell junction; centriolar satellite; cytoplasmic vesicle; dopaminergic synapse; early endosome; endosome; external side of plasma membrane; flotillin complex; GABA-ergic synapse; glutamatergic synapse; lamellipodium; membrane; membrane raft; microtubule organizing center; plasma membrane; plasma membrane raft; presynapse; presynaptic active zone; sarcolemma; synapse; uropod
Molecular Function:  ionotropic glutamate receptor binding; protease binding; protein binding; protein heterodimerization activity
Biological Process:  axon guidance; axonogenesis; cellular response to exogenous dsRNA; dsRNA transport; endocytosis; extracellular matrix disassembly; membrane raft assembly; plasma membrane raft assembly; positive regulation of cell adhesion molecule production; positive regulation of cell junction assembly; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cytokine production; positive regulation of endocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of interferon-beta production; positive regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of skeletal muscle tissue development; positive regulation of synaptic transmission, dopaminergic; positive regulation of toll-like receptor 3 signaling pathway; protein homooligomerization; protein kinase C signaling; protein localization to membrane raft; protein localization to plasma membrane; protein stabilization; regulation of neurotransmitter uptake; regulation of receptor internalization; regulation of Rho protein signal transduction; response to endoplasmic reticulum stress
Reference #:  O08917 (UniProtKB)
Alt. Names/Synonyms: Flot1; flotillin 1; Flotillin-1; reggie; reggie-2
Gene Symbols: Flot1
Molecular weight: 47,513 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene