NRP1 The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. Belongs to the neuropilin family. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 8 E2|8 75.78 cM
Cellular Component:  axon; cell surface; cytosol; early endosome; focal adhesion; glutamatergic synapse; growth cone; integral component of membrane; integral component of postsynaptic membrane; membrane; neurofilament; neuron projection; neuronal cell body; plasma membrane; sorting endosome
Molecular Function:  growth factor binding; GTPase activator activity; heparin binding; metal ion binding; protein binding; protein kinase binding; semaphorin receptor activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity
Biological Process:  actin cytoskeleton reorganization; angiogenesis; angiogenesis involved in coronary vascular morphogenesis; animal organ morphogenesis; artery morphogenesis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; axonogenesis involved in innervation; basal dendrite arborization; basal dendrite development; branching involved in blood vessel morphogenesis; branchiomotor neuron axon guidance; cell differentiation; cell migration; cell migration involved in coronary vasculogenesis; cell migration involved in sprouting angiogenesis; cellular response to hepatocyte growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; commissural neuron axon guidance; coronary artery morphogenesis; dendrite development; dichotomous subdivision of terminal units involved in salivary gland branching; dorsal root ganglion morphogenesis; endothelial cell chemotaxis; endothelial cell migration; facial nerve structural organization; facioacoustic ganglion development; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; heart development; hepatocyte growth factor receptor signaling pathway; integrin-mediated signaling pathway; motor neuron axon guidance; motor neuron migration; multicellular organism development; negative regulation of axon extension; negative regulation of axon extension involved in axon guidance; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; nerve development; nervous system development; neural crest cell migration involved in autonomic nervous system development; neuron development; neuron migration; neuropilin signaling pathway; otic placode development; outflow tract septum morphogenesis; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of actin cytoskeleton reorganization; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of filopodium assembly; positive regulation of focal adhesion assembly; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of retinal ganglion cell axon guidance; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; postsynapse organization; protein localization to early endosome; regulation of axon extension involved in axon guidance; regulation of Cdc42 protein signal transduction; regulation of retinal ganglion cell axon guidance; renal artery morphogenesis; retina vasculature morphogenesis in camera-type eye; retinal ganglion cell axon guidance; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance; semaphorin-plexin signaling pathway involved in neuron projection guidance; sensory neuron axon guidance; sprouting angiogenesis; substrate adhesion-dependent cell spreading; substrate-dependent cell migration, cell extension; sympathetic ganglion development; sympathetic nervous system development; sympathetic neuron projection extension; sympathetic neuron projection guidance; toxin transport; trigeminal ganglion development; trigeminal nerve morphogenesis; trigeminal nerve structural organization; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; VEGF-activated neuropilin signaling pathway; VEGF-activated neuropilin signaling pathway involved in axon guidance; ventral trunk neural crest cell migration; vestibulocochlear nerve structural organization
Reference #:  P97333 (UniProtKB)
Alt. Names/Synonyms: A5 protein; C530029I03; neuropilin 1; Neuropilin-1; Neuropilin-1 precursor (A5 protein); NP-1; NPN-1; Npn1; Nrp; Nrp1; transmembrane receptor
Gene Symbols: Nrp1
Molecular weight: 103,000 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene