SLC1A4 Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 2p14
Cellular Component:  centrosome; dendrite; integral component of membrane; integral component of plasma membrane; intermediate filament; melanosome; microtubule organizing center; neuronal cell body; plasma membrane
Molecular Function:  amino acid transmembrane transporter activity; chloride channel activity; L-alanine transmembrane transporter activity; L-cystine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-hydroxyproline transmembrane transporter activity; L-proline transmembrane transporter activity; L-serine transmembrane transporter activity; L-threonine transmembrane transporter activity; symporter activity
Biological Process:  amino acid transport; chloride transmembrane transport; cognition; glutamine transport; hydroxyproline transport; L-alanine transport; L-cystine transport; L-serine transport; proline transmembrane transport; proline transport; synaptic transmission, glutamatergic; threonine transport
Disease: Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Reference #:  P43007 (UniProtKB)
Alt. Names/Synonyms: Alanine/serine/cysteine/threonine transporter 1; ASCT-1; ASCT1; glutamate/neutral amino acid transporter; Neutral amino acid transporter A; SATT; SLC1A4; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Solute carrier family 1 member 4; SPATCCM
Gene Symbols: SLC1A4
Molecular weight: 55,723 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein