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STEAP1
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. Ubiquitously expressed. Highly expressed in prostate tumors. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 5 A1|5 3.2 cM |
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Cellular Component:
endosome; membrane; plasma membrane
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Molecular Function:
cupric reductase activity; ferric-chelate reductase (NADPH) activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
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Biological Process:
copper ion import; iron ion import across cell outer membrane; iron ion transmembrane transport; monoatomic ion transport
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Reference #:
Q9CWR7
(UniProtKB)
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Alt. Names/Synonyms: 2410007B19Rik; Metalloreductase STEAP1; OTTMUSP00000031726; Prss24; six transmembrane epithelial antigen of the prostate 1; Six-transmembrane epithelial antigen of prostate 1; STEA1; Steap; Steap1; STEAP1 protein
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Gene Symbols: Steap1
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Molecular weight:
39,292 Da
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Basal Isoelectric point:
9.26
Predict pI for various phosphorylation states
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