SASH1 May have a role in a signaling pathway. Could act as a tumor suppressor. Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of mouse Ortholog: 10|10 A1
Cellular Component:  cytoplasm; membrane; protein-containing complex
Molecular Function:  G-protein alpha-subunit binding; mitogen-activated protein kinase kinase kinase binding; molecular adaptor activity; protein binding; protein kinase binding
Biological Process:  positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; positive regulation of p38MAPK cascade; protein polyubiquitination; regulation of epithelial cell migration; regulation of protein autoubiquitination; regulation of protein K63-linked ubiquitination
Reference #:  P59808 (UniProtKB)
Alt. Names/Synonyms: 1100001C18Rik; 2500002E12Rik; A330076K04Rik; mKIAA0790; putative adapter and scaffold protein 1; SAM and SH3 domain containing 1; SAM and SH3 domain-containing protein 1; Sash1
Gene Symbols: Sash1
Molecular weight: 135,591 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below

SASH1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein