SASH1 May have a role in a signaling pathway. Could act as a tumor suppressor. Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 6q24.3-q25.1
Cellular Component:  protein-containing complex
Molecular Function:  mitogen-activated protein kinase kinase kinase binding; molecular adaptor activity; protein C-terminus binding; protein kinase binding
Biological Process:  positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; positive regulation of p38MAPK cascade; protein polyubiquitination; regulation of protein autoubiquitination; regulation of protein K63-linked ubiquitination
Disease: Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma; Dyschromatosis Universalis Hereditaria 1
Reference #:  O94885 (UniProtKB)
Alt. Names/Synonyms: 2500002E12Rik; dJ323M4; dJ323M4.1; KIAA0790; PEPE1; Proline-glutamate repeat-containing protein; RP3-323M4.1; SAM and SH3 domain containing 1; SAM and SH3 domain-containing protein 1; SASH1; SH3D6A
Gene Symbols: SASH1
Molecular weight: 136,653 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein