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MISP
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. Belongs to the MISP family. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 10|10 C1 |
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Cellular Component:
actin filament; anchoring junction; cortical actin cytoskeleton; cytoplasm; cytoskeleton; focal adhesion; intracellular membrane-bounded organelle; mitotic spindle astral microtubule end; plasma membrane; spindle pole centrosome
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Molecular Function:
actin binding; actin filament binding
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Biological Process:
cell cycle; cell division; cell migration; establishment of centrosome localization; establishment of mitotic spindle orientation; mitotic spindle assembly; organelle localization; regulation of protein localization to cell cortex
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Reference #:
Q9D279
(UniProtKB)
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Alt. Names/Synonyms: 9130017N09Rik; CS021; hypothetical protein LOC78906; MISP; Mitotic interactor and substrate of PLK1; mitotic spindle positioning; Mitotic spindle positioning protein; RIKEN cDNA 9130017N09 gene; Uncharacterized protein C19orf21 homolog
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Gene Symbols: Misp
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Molecular weight:
72,281 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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