PIK4CA Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16|16 A3
Cellular Component:  cytoplasm; Golgi-associated vesicle membrane; membrane; plasma membrane; viral replication complex
Molecular Function:  1-phosphatidylinositol 4-kinase activity; ATP binding; kinase activity; nucleotide binding; transferase activity
Biological Process:  multi-organism membrane organization; phosphatidylinositol phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; viral replication complex formation and maintenance; viral RNA genome replication
Reference #:  E9Q3L2 (UniProtKB)
Alt. Names/Synonyms: Phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase type 3 alpha; Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; PI4-kinase alpha; PI4K-alpha; Pi4ka; Pik; Pik4; Pik4ca; PtdIns-4-kinase alpha
Gene Symbols: Pi4ka
Molecular weight: 237,042 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PIK4CA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene