PIK4CA Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component:  cytoplasm; cytosol; Golgi-associated vesicle membrane; plasma membrane; viral replication complex
Molecular Function:  1-phosphatidylinositol 4-kinase activity; ATP binding; kinase activity; protein binding
Biological Process:  multi-organism membrane organization; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation; phosphorylation; signal transduction; viral replication complex formation and maintenance; viral RNA genome replication
Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis
Reference #:  P42356 (UniProtKB)
Alt. Names/Synonyms: FLJ16556; phosphatidylinositol 4-kinase 230; Phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase III alpha; phosphatidylinositol 4-kinase IIII+/-; phosphatidylinositol 4-kinase, catalytic, alpha; phosphatidylinositol 4-kinase, type III, alpha; PI4-kinase alpha; PI4K-alpha; pi4K230; PI4KA; PIK4; PIK4CA; PMGYCHA; PtdIns-4-kinase alpha; testicular secretory protein Li 35
Gene Symbols: PI4KA
Molecular weight: 236,830 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK4CA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein