ANXA5 a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Calcium-binding; Inhibitor; Lipid-binding
Chromosomal Location of Human Ortholog: 3 B|3 17.46 cM
Cellular Component:  axon terminus; cell projection; cytoplasm; cytosol; dendrite; endoplasmic reticulum; endothelial microparticle; external side of plasma membrane; extracellular space; intercalated disc; membrane; neuronal cell body; nucleus; perikaryon; plasma membrane; sarcolemma; synaptic vesicle; Z disc
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; calcium-transporting ATPase activity; heparin binding; peptide hormone binding; protein binding; receptor tyrosine kinase binding
Biological Process:  blood coagulation; cellular response to gonadotropin-releasing hormone; cellular response to lead ion; hemostasis; negative regulation of blood coagulation; negative regulation of coagulation; negative regulation of prolactin secretion; negative regulation of sequestering of calcium ion; positive regulation of apoptotic process; protein homooligomerization; regulation of flagellated sperm motility; response to calcium ion; response to organic substance; response to thyroid hormone
Reference #:  P48036 (UniProtKB)
Alt. Names/Synonyms: Anchorin CII; Annexin A5; Annexin V; Annexin-5; Anx5; Anxa5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; OTTMUSP00000021966; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PP4; R74653; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha
Gene Symbols: Anxa5
Molecular weight: 35,752 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein