Claudin-2 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: X|X F1
Cellular Component:  bicellular tight junction; cell junction; integral component of membrane; membrane; plasma membrane
Molecular Function:  identical protein binding; protein binding; structural molecule activity
Biological Process:  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Reference #:  O88552 (UniProtKB)
Alt. Names/Synonyms: AL022813; claudin 2; Claudin-2; claudin2; CLD2; Cldn2; OTTMUSP00000020257
Gene Symbols: Cldn2
Molecular weight: 24,484 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene