Claudin-2 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: Xq22.3
Cellular Component:  bicellular tight junction; integral component of membrane; plasma membrane
Molecular Function:  identical protein binding; protein binding; structural molecule activity
Biological Process:  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Disease: Azoospermia, Obstructive, With Nephrolithiasis
Reference #:  P57739 (UniProtKB)
Alt. Names/Synonyms: claudin 2; Claudin-2; claudin2; CLD2; CLDN2; SP82
Gene Symbols: CLDN2
Molecular weight: 24,549 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein