EphB2 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component:  axon; cytosol; dendrite; extracellular region; glutamatergic synapse; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; neuronal cell body; nucleus; plasma membrane; postsynapse
Molecular Function:  amyloid-beta binding; ATP binding; axon guidance receptor activity; identical protein binding; protein binding; protein tyrosine kinase activity; protein-containing complex binding; signaling receptor binding; transmembrane-ephrin receptor activity
Biological Process:  angiogenesis; axon guidance; axonal fasciculation; camera-type eye morphogenesis; commissural neuron axon guidance; corpus callosum development; dendritic spine development; dendritic spine morphogenesis; ephrin receptor signaling pathway; inactivation of MAPKK activity; inner ear morphogenesis; learning; learning or memory; negative regulation of axonogenesis; negative regulation of ERK1 and ERK2 cascade; negative regulation of NMDA glutamate receptor activity; negative regulation of protein phosphorylation; negative regulation of Ras protein signal transduction; nervous system development; neuron projection retraction; optic nerve morphogenesis; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of gene expression; positive regulation of long-term neuronal synaptic plasticity; positive regulation of long-term synaptic potentiation; positive regulation of NMDA glutamate receptor activity; positive regulation of protein localization to plasma membrane; positive regulation of synapse assembly; positive regulation of synaptic plasticity; postsynaptic membrane assembly; regulation of body fluid levels; regulation of neuronal synaptic plasticity; retinal ganglion cell axon guidance; roof of mouth development; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; urogenital system development
Disease: Bleeding Disorder, Platelet-type, 22; Prostate Cancer/brain Cancer Susceptibility
Reference #:  P29323 (UniProtKB)
Alt. Names/Synonyms: BDPLT22; CAPB; Developmentally-regulated Eph-related tyrosine kinase; DRT; EK5; elk-related tyrosine kinase; EPH receptor B2; eph tyrosine kinase 3; EPH-like kinase 5; EPHB2; EphB2/CTF1; EphB2/CTF2; Ephrin type-B receptor 2; EPHT3; EPTH3; ERK; HEK5; MGC87492; PCBC; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; TYRO5; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase TYRO5
Gene Symbols: EPHB2
Molecular weight: 117,493 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein