|
EDF1
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; Nuclear receptor co-regulator; RNA-binding; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 2|2 A3 |
|
Cellular Component:
cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
|
|
Molecular Function:
calmodulin binding; DNA binding; TFIID-class transcription factor complex binding; transcription coactivator activity
|
|
Biological Process:
cell differentiation; multicellular organism development; positive regulation of DNA binding
|
|
Reference #:
Q9JMG1
(UniProtKB)
|
|
Alt. Names/Synonyms: 0610008L11Rik; AA409425; EDF-1; Edf1; Endothelial differentiation-related factor 1; hypothetical protein 1-9; MBF1; Multiprotein-bridging factor 1; OTTMUSP00000013111
|
|
Gene Symbols: Edf1
|
|
Molecular weight:
16,369 Da
|
|
Basal Isoelectric point:
9.99
Predict pI for various phosphorylation states
|
