EDF1 Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleus
Molecular Function:  calmodulin binding; protein binding; sequence-specific DNA binding; TFIID-class transcription factor complex binding; transcription coactivator activity
Biological Process:  endothelial cell differentiation; multicellular organism development; positive regulation of DNA binding; positive regulation of transcription, DNA-templated; regulation of lipid metabolic process; regulation of transcription, DNA-templated
Reference #:  O60869 (UniProtKB)
Alt. Names/Synonyms: EDF-1; EDF1; Endothelial differentiation-related factor 1; MBF1; MGC9058; multiprotein bridging factor 1; multiprotein bridging factor-1; Multiprotein-bridging factor 1
Gene Symbols: EDF1
Molecular weight: 16,369 Da
Basal Isoelectric point: 9.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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