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CPNE3
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation. Belongs to the copine family. Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870). Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Lipid-binding |
| Chromosomal Location of mouse Ortholog: 4|4 A3 |
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Cellular Component:
anchoring junction; cell junction; cytoplasm; cytosol; focal adhesion; membrane; mitochondrion; nucleolus; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
calcium-dependent phospholipid binding; calcium-dependent protein binding; metal ion binding; protein serine/threonine kinase activity; receptor tyrosine kinase binding
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Biological Process:
cellular response to calcium ion; cellular response to growth factor stimulus; ERBB2 signaling pathway; positive regulation of cell migration
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Reference #:
Q8BT60
(UniProtKB)
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Alt. Names/Synonyms: 5430428M23Rik; 5730450C07Rik; C85108; Copine III; Copine-3; CPN3; Cpne3; Kiaa0636; OTTMUSP00000004950; PRO1
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Gene Symbols: Cpne3
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Molecular weight:
59,585 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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