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DOK1
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. Belongs to the DOK family. Type A subfamily. Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2p13.1 |
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Cellular Component:
cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm
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Molecular Function:
protein binding
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Biological Process:
cell surface receptor signaling pathway; macrophage colony-stimulating factor signaling pathway; positive regulation of MAPK cascade; Ras protein signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q99704
(UniProtKB)
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Alt. Names/Synonyms: Docking protein 1; docking protein 1 (downstream of tyrosine kinase 1); docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK1; Downstream of tyrosine kinase 1; MGC117395; MGC138860; p62(dok); P62DOK; pp62
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Gene Symbols: DOK1
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Molecular weight:
52,392 Da
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Basal Isoelectric point:
6.05
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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