CRIM1 May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17|17 E2
Cellular Component:  extracellular region; integral component of membrane; membrane
Molecular Function:  enzyme inhibitor activity; insulin-like growth factor binding; PDZ domain binding; serine-type endopeptidase inhibitor activity
Reference #:  Q9JLL0 (UniProtKB)
Alt. Names/Synonyms: AU015004; CRIM-1; Crim1; cysteine rich transmembrane BMP regulator 1 (chordin like); Cysteine-rich motor neuron 1 protein
Gene Symbols: Crim1
Molecular weight: 114,066 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene