CRIM1 May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2p22.2
Cellular Component:  extracellular region; integral component of membrane; plasma membrane
Molecular Function:  insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; PDZ domain binding; serine-type endopeptidase inhibitor activity
Biological Process:  insulin-like growth factor receptor signaling pathway; negative regulation of endopeptidase activity; nervous system development
Reference #:  Q9NZV1 (UniProtKB)
Alt. Names/Synonyms: CRIM-1; CRIM1; cysteine rich transmembrane BMP regulator 1 (chordin-like); Cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52; MGC138194; Processed cysteine-rich motor neuron 1 protein; S52
Gene Symbols: CRIM1
Molecular weight: 113,738 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Select Structure to View Below

CRIM1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene