CRIM1 May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2p22.2
Cellular Component:  extracellular region; integral component of membrane; plasma membrane
Molecular Function:  insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; PDZ domain binding; serine-type endopeptidase inhibitor activity
Biological Process:  insulin-like growth factor receptor signaling pathway; negative regulation of endopeptidase activity; nervous system development
Reference #:  Q9NZV1 (UniProtKB)
Alt. Names/Synonyms: CRIM-1; CRIM1; cysteine rich transmembrane BMP regulator 1; cysteine rich transmembrane BMP regulator 1 (chordin-like); Cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52; MGC138194; Processed cysteine-rich motor neuron 1 protein; S52
Gene Symbols: CRIM1
Molecular weight: 113,738 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene