SNX27 Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component:  cytoplasm; cytosol; early endosome; endosome; immunological synapse; membrane; nucleoplasm; plasma membrane; postsynaptic density
Molecular Function:  ionotropic glutamate receptor binding; lipid binding; phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding; protein binding
Biological Process:  endosomal transport; endosome to lysosome transport; endosome to plasma membrane protein transport; establishment of protein localization to plasma membrane; intracellular protein transport; negative regulation of inward rectifier potassium channel activity; positive regulation of AMPA glutamate receptor clustering; protein transport; retrograde transport, endosome to plasma membrane; signal transduction
Reference #:  Q3UHD6 (UniProtKB)
Alt. Names/Synonyms: 5730552M22Rik; ESTM45; Kiaa0488; mKIAA0488; OTTMUSP00000021101; OTTMUSP00000021102; R75405; Snx27; sorting nexin family member 27; Sorting nexin-27
Gene Symbols: Snx27
Molecular weight: 60,989 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene