SNX27 Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. Belongs to the sorting nexin family. Widely expressed. Expressed in cells of hematopoietic origin (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component:  cytoplasm; cytosol; early endosome; endosome; immunological synapse; membrane; nucleoplasm; plasma membrane; postsynaptic density
Molecular Function:  ionotropic glutamate receptor binding; lipid binding; phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding; protein binding
Biological Process:  endosomal transport; endosome to lysosome transport; endosome to plasma membrane protein transport; establishment of protein localization to plasma membrane; intracellular protein transport; negative regulation of inward rectifier potassium channel activity; positive regulation of AMPA glutamate receptor clustering; protein transport; retrograde transport, endosome to plasma membrane; signal transduction
Reference #:  Q3UHD6 (UniProtKB)
Alt. Names/Synonyms: 5730552M22Rik; ESTM45; Kiaa0488; mKIAA0488; OTTMUSP00000021101; OTTMUSP00000021102; R75405; Snx27; sorting nexin family member 27; Sorting nexin-27
Gene Symbols: Snx27
Molecular weight: 60,989 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene