SNX27 Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. Belongs to the sorting nexin family. Widely expressed. Expressed in cells of hematopoietic origin (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 1q21.3
Cellular Component:  cytosol; early endosome; early endosome membrane; endosome; glutamatergic synapse; immunological synapse; intracellular membrane-bounded organelle; Schaffer collateral - CA1 synapse
Molecular Function:  phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding; protein binding
Biological Process:  endocytic recycling; endosomal transport; endosome to lysosome transport; establishment of natural killer cell polarity; intracellular protein transport; regulation of postsynaptic membrane neurotransmitter receptor levels; signal transduction
Reference #:  Q96L92 (UniProtKB)
Alt. Names/Synonyms: KIAA0488; methamphetamine-responsive transcript 1; MGC126871; MGC126873; MGC20471; MRT1; MY014; SNX27; sorting nexin 27; sorting nexin family member 27; Sorting nexin-27
Gene Symbols: SNX27
Molecular weight: 61,265 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein