PAR-4 Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of mouse Ortholog: 10|10 D1
Cellular Component:  actin cytoskeleton; actin filament; axon; chromatin; cytoplasm; cytosol; neuronal cell body; nucleus; plasma membrane
Molecular Function:  actin binding; enzyme binding; leucine zipper domain binding; protein binding; protein kinase C binding; protein phosphatase 1 binding
Biological Process:  actin filament bundle assembly; activation of cysteine-type endopeptidase activity; apoptotic process; apoptotic signaling pathway; calcium ion import across plasma membrane; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; interleukin-2 production; negative regulation of B cell proliferation; negative regulation of calcium ion import; negative regulation of epithelial to mesenchymal transition; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of action potential; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptotic process; positive regulation of cellular senescence; positive regulation of gene expression; positive regulation of hindgut contraction; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of leukocyte tethering or rolling; positive regulation of neuron apoptotic process; positive regulation of neuronal action potential; positive regulation of neutrophil extravasation; positive regulation of phosphoprotein phosphatase activity; positive regulation of relaxation of smooth muscle
Reference #:  Q925B0 (UniProtKB)
Alt. Names/Synonyms: 2310001G03Rik; Par-4; Par4; Pawr; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein
Gene Symbols: Pawr
Molecular weight: 35,908 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene