PAR-4 a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 12q21.2
Cellular Component:  cytoplasm; nuclear chromatin; nucleus
Molecular Function:  actin binding; enzyme binding; leucine zipper domain binding; protein binding; transcription corepressor activity
Biological Process:  actin filament bundle assembly; apoptotic process; apoptotic signaling pathway; interleukin-2 biosynthetic process; negative regulation of B cell proliferation; negative regulation of fibroblast proliferation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptotic process; positive regulation of cellular senescence; positive regulation of gene expression; positive regulation of hydrogen peroxide-mediated programmed cell death
Reference #:  Q96IZ0 (UniProtKB)
Alt. Names/Synonyms: Par-4; PAR4; PAWR; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; transcriptional repressor PAR4; WT1-interacting protein
Gene Symbols: PAWR
Molecular weight: 36,568 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAR-4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene