profilin 2 Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Belongs to the profilin family. Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3 D|3 28.15 cM
Cellular Component:  cytoplasm; cytoskeleton; glutamatergic synapse; postsynapse; presynapse; Schaffer collateral - CA1 synapse; terminal bouton
Molecular Function:  actin binding; actin monomer binding; ATPase activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process:  actin cytoskeleton organization; modification of postsynaptic actin cytoskeleton; negative regulation of actin filament polymerization; negative regulation of epithelial cell migration; negative regulation of ruffle assembly; positive regulation of actin filament bundle assembly; positive regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress fiber assembly; protein stabilization; regulation of actin filament polymerization; regulation of synaptic vesicle exocytosis
Reference #:  Q9JJV2 (UniProtKB)
Alt. Names/Synonyms: Pfn; Pfn2; PROF2; profilin 2; Profilin II; Profilin-2
Gene Symbols: Pfn2
Molecular weight: 15,032 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

profilin 2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene