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profilin 2
binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. Profilin IIa interacts with the ROCK kinase to regulate actin stability during neuritogenesis. By binding to PIP2, it inhibits the formation of IP3 and DG. Belongs to the profilin family. Two alternatively spliced human isoforms have been reported. Both isoforms are largely restricted to brain. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 3 D|3 28.15 cM |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; glutamatergic synapse; postsynapse; presynapse; Schaffer collateral - CA1 synapse
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Molecular Function:
actin binding; actin monomer binding; ATP hydrolysis activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding
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Biological Process:
actin cytoskeleton organization; modification of postsynaptic actin cytoskeleton; modulation of chemical synaptic transmission; negative regulation of actin filament polymerization; negative regulation of epithelial cell migration; negative regulation of ruffle assembly; positive regulation of actin filament bundle assembly; positive regulation of actin filament polymerization; positive regulation of ATP-dependent activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress fiber assembly; presynaptic modulation of chemical synaptic transmission; protein stabilization; regulation of actin filament polymerization; regulation of synaptic vesicle exocytosis
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Reference #:
Q9JJV2
(UniProtKB)
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Alt. Names/Synonyms: Pfn; Pfn2; PROF2; profilin 2; Profilin II; Profilin-2
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Gene Symbols: Pfn2
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Molecular weight:
15,032 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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