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CTNND2
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Belongs to the beta-catenin family. Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 5p15.2 |
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Cellular Component:
adherens junction; cytoplasm; dendrite; nucleus; perikaryon; plasma membrane; postsynaptic density
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Molecular Function:
beta-catenin binding; cadherin binding; protein binding
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Biological Process:
cell adhesion; cell-cell adhesion; cell-cell junction assembly; dendritic spine morphogenesis; regulation of canonical Wnt signaling pathway; signal transduction; synapse organization; Wnt signaling pathway
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Disease: Cri-du-chat Syndrome
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Reference #:
Q9UQB3
(UniProtKB)
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Alt. Names/Synonyms: catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); catenin delta 2; Catenin delta-2; CTND2; CTNND2; Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; Neurojungin; NPRAP; T-cell delta-catenin
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Gene Symbols: CTNND2
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Molecular weight:
132,656 Da
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Basal Isoelectric point:
7.78
Predict pI for various phosphorylation states
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