CTNND2 Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Belongs to the beta-catenin family. Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5p15.2
Cellular Component:  dendrite; perikaryon
Molecular Function:  beta-catenin binding; protein binding
Biological Process:  cell adhesion; dendritic spine morphogenesis; regulation of canonical Wnt signaling pathway; signal transduction; synapse organization; Wnt signaling pathway
Disease: Cri-du-chat Syndrome
Reference #:  Q9UQB3 (UniProtKB)
Alt. Names/Synonyms: catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); Catenin delta-2; CTND2; CTNND2; Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; Neurojungin; NPRAP; T-cell delta-catenin
Gene Symbols: CTNND2
Molecular weight: 132,656 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
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CTNND2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB