SHANK1 Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component:  cell junction; cytosol; dendrite; dendritic spine; excitatory synapse; glutamatergic synapse; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  ankyrin repeat binding; GKAP/Homer scaffold activity; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein C-terminus binding; protein-containing complex binding; scaffold protein binding; SH3 domain binding; somatostatin receptor binding
Biological Process:  adult behavior; associative learning; cytoskeletal anchoring at plasma membrane; dendritic spine morphogenesis; determination of affect; habituation; long-term memory; negative regulation of actin filament bundle assembly; neuromuscular process controlling balance; olfactory behavior; positive regulation of dendritic spine development; positive regulation of excitatory postsynaptic potential; protein localization to synapse; protein-containing complex assembly; regulation of AMPA receptor activity; righting reflex; social behavior; synapse maturation; vocalization behavior
Reference #:  Q9Y566 (UniProtKB)
Alt. Names/Synonyms: SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SHAN1; SHANK1; Somatostatin receptor-interacting protein; SPANK-1; SSTR-interacting protein; SSTRIP; synamon
Gene Symbols: SHANK1
Molecular weight: 224,959 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene