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atlastin
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.5.-; Membrane protein, integral; Membrane protein, multi-pass; Vesicle |
| Chromosomal Location of human Ortholog: 14q22.1 |
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Cellular Component:
axon; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network membrane; Golgi apparatus; Golgi cis cisterna; Golgi membrane; membrane
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Molecular Function:
GTP binding; GTPase activity; identical protein binding; protein binding
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Biological Process:
axonogenesis; endoplasmic reticulum organization; endoplasmic reticulum tubular network membrane organization; protein homooligomerization
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Disease: Neuropathy, Hereditary Sensory, Type Id; Spastic Paraplegia 3, Autosomal Dominant
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Reference #:
Q8WXF7
(UniProtKB)
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Alt. Names/Synonyms: AD-FSP; ATL1; ATLA1; atlastin; atlastin GTPase 1; Atlastin-1; atlastin1; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; guanylate-binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG3; SPG3A
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Gene Symbols: ATL1
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Molecular weight:
63,544 Da
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Basal Isoelectric point:
5.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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