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WEE1B
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. Expressed in oocytes (at protein level) (PubMed:29606300). May also be expressed in testis (PubMed:11029659). Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); WEE family; WEE1 subfamily |
| Chromosomal Location of mouse Ortholog: 6|6 B1 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
ATP binding; kinase activity; magnesium ion binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity
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Biological Process:
female meiotic nuclear division; female pronucleus assembly; meiotic cell cycle; mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of oocyte maturation; phosphorylation; positive regulation of phosphorylation; protein phosphorylation; regulation of fertilization; regulation of meiosis I
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Reference #:
Q66JT0
(UniProtKB)
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Alt. Names/Synonyms: Gm1065; MGC60753; mWee1B; OTTMUSP00000026931; WEE1 homolog 2 (S. pombe); Wee1-like protein kinase 1B; Wee1-like protein kinase 2; Wee1b; Wee1B kinase; Wee2
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Gene Symbols: Wee2
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Molecular weight:
62,343 Da
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Basal Isoelectric point:
6.53
Predict pI for various phosphorylation states
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