ADCY9 Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  axon; dendrite; integral component of membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; metal ion binding
Biological Process:  activation of adenylate cyclase activity; activation of protein kinase A activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to glucagon stimulus; G protein-coupled receptor signaling pathway; renal water homeostasis; signal transduction
Reference #:  O60503 (UniProtKB)
Alt. Names/Synonyms: AC9; ACIX; ADCY9; adenylate cyclase 9; Adenylate cyclase type 9; Adenylate cyclase type IX; Adenylyl cyclase 9; ATP pyrophosphate-lyase 9; KIAA0520; type IX ATP pyrophosphate-lyase
Gene Symbols: ADCY9
Molecular weight: 150,701 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB