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ADCY9
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). Note: This description may include information from UniProtKB.
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| Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
axon; cytosol; dendrite; membrane; plasma membrane
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Molecular Function:
adenylate cyclase activity; ATP binding; metal ion binding
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Biological Process:
adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; in utero embryonic development; intracellular signal transduction; signal transduction
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Reference #:
O60503
(UniProtKB)
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Alt. Names/Synonyms: AC9; ACIX; ADCY9; adenylate cyclase 9; Adenylate cyclase type 9; Adenylate cyclase type IX; Adenylyl cyclase 9; ATP pyrophosphate-lyase 9; KIAA0520; type IX ATP pyrophosphate-lyase
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Gene Symbols: ADCY9
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Molecular weight:
150,701 Da
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Basal Isoelectric point:
7.07
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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NF-kB Signaling
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Parkinson's Disease
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