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NCAM-L1
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
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Cellular Component:
axon; axonal growth cone; plasma membrane
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Molecular Function:
cell-cell adhesion mediator activity
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Biological Process:
axon guidance; dendrite self-avoidance; homophilic cell adhesion via plasma membrane adhesion molecules
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Reference #:
Q90933
(UniProtKB)
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Alt. Names/Synonyms: L1 cell adhesion molecule; L1CAM; NCAM-L1; Neuron-glia cell adhesion molecule; Neuron-glia cell adhesion molecule (Ng-CAM); Ng-CAM
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Gene Symbols: L1CAM
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Molecular weight:
136,571 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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