HER3 a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component:  apical plasma membrane; basolateral plasma membrane; extracellular space; lateral plasma membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; growth factor binding; identical protein binding; neuregulin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding
Biological Process:  cranial nerve development; endocardial cushion development; ERBB2 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; MAPK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neuron apoptotic process; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; regulation of cell motility; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Disease: Erythroleukemia, Familial, Susceptibility To; Lethal Congenital Contracture Syndrome 2
Reference #:  P21860 (UniProtKB)
Alt. Names/Synonyms: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Symbols: ERBB3
Molecular weight: 148,098 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HER3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein