HER3 Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Epithelial tissues and brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component:  apical plasma membrane; basolateral plasma membrane; extracellular space; lateral plasma membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; growth factor binding; identical protein binding; neuregulin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding
Biological Process:  cranial nerve development; endocardial cushion development; ERBB2 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; MAPK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neuron apoptotic process; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; regulation of cell motility; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Disease: Erythroleukemia, Familial, Susceptibility To; Lethal Congenital Contracture Syndrome 2; Visceral Neuropathy, Familial, 1, Autosomal Recessive
Reference #:  P21860 (UniProtKB)
Alt. Names/Synonyms: c-erbB-3; c-erbB3; erb-b2 receptor tyrosine kinase 3; ErbB-3; ERBB3; erbB3-S; FERLK; HER3; human epidermal growth factor receptor 3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Symbols: ERBB3
Molecular weight: 148,098 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein