SNIP Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Belongs to the SRCIN1 family. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 11|11 D
Cellular Component:  actin cytoskeleton; axon; cell projection; cytoplasm; cytoskeleton; dendrite; filopodium; focal adhesion; glutamatergic synapse; lamellipodium; neuron projection; neuronal cell body; postsynaptic density; synapse
Molecular Function:  protein binding; protein domain specific binding; protein kinase binding
Biological Process:  exocytosis; negative regulation of cell adhesion; negative regulation of protein secretion; negative regulation of protein tyrosine kinase activity; positive regulation of protein tyrosine kinase activity; regulation of cell migration; regulation of dendritic spine morphogenesis; regulation of synapse assembly; substrate adhesion-dependent cell spreading
Reference #:  Q9QWI6 (UniProtKB)
Alt. Names/Synonyms: Kiaa1684; mKIAA1684; OTTMUSP00000002552; p130Cas-associated protein; P14; P140; p140Cap; SNAP-25-interacting protein; SNIP; SRC kinase signaling inhibitor 1; Srcin1; SRCN1
Gene Symbols: P140
Molecular weight: 134,859 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene