SNIP Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Interacts with the N-terminal coiled-coil region of SNAP25. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Belongs to the SRCIN1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  actin cytoskeleton; axon; cell junction; cell projection; cytoplasm; cytoskeleton; dendrite; filopodium; lamellipodium; membrane; neuron projection; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic membrane; synapse
Molecular Function:  protein binding; protein domain specific binding; protein kinase binding
Biological Process:  exocytosis; negative regulation of cell adhesion; negative regulation of protein secretion; negative regulation of protein tyrosine kinase activity; positive regulation of protein tyrosine kinase activity; regulation of cell migration; regulation of dendritic spine morphogenesis; substrate adhesion-dependent cell spreading
Reference #:  Q9QWI6 (UniProtKB)
Alt. Names/Synonyms: Kiaa1684; mKIAA1684; OTTMUSP00000002552; p130Cas-associated protein; P140; p140Cap; SNAP-25-interacting protein; SNIP; SRC kinase signaling inhibitor 1; Srcin1; SRCN1
Gene Symbols: P140
Molecular weight: 134,859 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SNIP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene