SLC20A1 Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2 F1|2 62.79 cM
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  high-affinity inorganic phosphate:sodium symporter activity; inorganic phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; symporter activity
Biological Process:  biomineral tissue development; phosphate ion transmembrane transport; phosphate ion transport; sodium ion transport
Reference #:  Q61609 (UniProtKB)
Alt. Names/Synonyms: AI607883; Gibbon ape leukemia virus receptor 1; GLVR-1; Glvr1; Leukemia virus receptor 1 homolog; OTTMUSP00000016433; OTTMUSP00000016435; Phosphate transporter 1; PiT-1; Pit1; S20A1; Slc20a1; Sodium-dependent phosphate transporter 1; Solute carrier family 20 member 1; solute carrier family 20, member 1
Gene Symbols: Slc20a1
Molecular weight: 74,153 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
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SLC20A1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene