SGIP1
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. Specifically expressed in brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Vesicle |
Chromosomal Location of mouse Ortholog: 4|4 C6 |
Cellular Component:
AP-2 adaptor complex; clathrin-coated pit; cytoplasm; membrane; plasma membrane; presynapse
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Molecular Function:
microtubule binding; protein binding; RNA-directed DNA polymerase activity; SH3 domain binding; tubulin binding
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Biological Process:
clathrin-dependent endocytosis; endocytosis; energy homeostasis; positive regulation of eating behavior; positive regulation of feeding behavior; positive regulation of multicellular organism growth; response to dietary excess
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Reference #:
Q8VD37
(UniProtKB)
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Alt. Names/Synonyms: 3110007P09Rik; Endophilin-3-interacting protein; gag; OTTMUSP00000008378; Sgip1; SGIP1alpha; SH3-containing GRB2-like protein 3-interacting protein 1; SH3-domain GRB2-like (endophilin) interacting protein 1; SH3-domain GRB2-like interacting protein 1 alpha
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Gene Symbols: Sgip1
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Molecular weight:
86,063 Da
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Basal Isoelectric point:
7.95
Predict pI for various phosphorylation states
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