SGIP1 May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. Specifically expressed in brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 4|4 C6
Cellular Component:  AP-2 adaptor complex; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoskeleton; membrane; plasma membrane; presynapse
Molecular Function:  cytoskeletal protein binding; microtubule binding; phospholipid binding; protein binding; SH3 domain binding; tubulin binding
Biological Process:  clathrin coat assembly; clathrin-dependent endocytosis; endocytosis; energy homeostasis; plasma membrane tubulation; positive regulation of eating behavior; positive regulation of feeding behavior; positive regulation of multicellular organism growth; positive regulation of receptor-mediated endocytosis; response to dietary excess
Reference #:  Q8VD37 (UniProtKB)
Alt. Names/Synonyms: 3110007P09Rik; Endophilin-3-interacting protein; gag; OTTMUSP00000008378; Sgip1; SGIP1alpha; SH3-containing GRB2-like protein 3-interacting protein 1; SH3-domain GRB2-like (endophilin) interacting protein 1; SH3-domain GRB2-like interacting protein 1 alpha
Gene Symbols: Sgip1
Molecular weight: 86,063 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene