NEK7 Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; NEK6 subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 1 E4|1 60.82 cM
Cellular Component:  cytoplasm; cytoskeleton; microtubule organizing center; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to potassium ion; peptidyl-serine phosphorylation; phosphorylation; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of mitotic cell cycle
Reference #:  Q9ES74 (UniProtKB)
Alt. Names/Synonyms: 2810460C19Rik; AU020186; Nek7; Never in mitosis A-related kinase 7; NIMA (never in mitosis gene a)-related expressed kinase 7; NIMA-related expressed kinase 7; NIMA-related kinase 7; NimA-related protein kinase 7; Serine/threonine-protein kinase Nek7
Gene Symbols: Nek7
Molecular weight: 34,537 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein