CACNB4 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. Expressed predominantly in the cerebellum and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium
Chromosomal Location of Human Ortholog: 2 C1.1|2 29.98 cM
Cellular Component:  cytoplasm; glutamatergic synapse; nuclear speck; nucleolus; plasma membrane; presynapse; synapse; voltage-gated calcium channel complex
Molecular Function:  calcium channel activity; high voltage-gated calcium channel activity; protein binding; protein kinase binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels; voltage-gated ion channel activity
Biological Process:  adult walking behavior; calcium ion transport; cAMP metabolic process; cellular calcium ion homeostasis; cellular response to leukemia inhibitory factor; chemical synaptic transmission; detection of light stimulus involved in visual perception; gamma-aminobutyric acid secretion; gamma-aminobutyric acid signaling pathway; ion transport; muscle fiber development; negative regulation of cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; nervous system process; neuromuscular junction development; neuronal action potential propagation; Peyer's patch development; positive regulation of protein localization to nucleolus; positive regulation of voltage-gated calcium channel activity; regulation of ion transmembrane transport; regulation of membrane potential; regulation of synaptic vesicle exocytosis; regulation of voltage-gated calcium channel activity; spleen development; synaptic transmission, glutamatergic; T cell receptor signaling pathway; thymus development
Reference #:  Q8R0S4 (UniProtKB)
Alt. Names/Synonyms: 3110038O15Rik; CAB4; CACB4; Cacnb4; Cacnlb4; Calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; Cchb4; lethargic; lh; MGC31529; OTTMUSP00000013499; OTTMUSP00000013519; Voltage-dependent L-type calcium channel subunit beta-4
Gene Symbols: Cacnb4
Molecular weight: 57,950 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
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CACNB4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene