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SHISA7
Regulator of long-term synaptic potentiation specifically involved in the formation and retrieval of hippocampus-dependent contextual fear memory. Probably regulates induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses by affecting the recruitment of AMPA-type glutamate receptor (AMPAR) at postsynaptic density. Belongs to the shisa family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 7|7 A1 |
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Cellular Component:
AMPA glutamate receptor complex; asymmetric, glutamatergic, excitatory synapse; cell junction; dendritic spine membrane; glutamatergic synapse; integral component of membrane; integral component of postsynaptic specialization membrane; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; synapse
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Molecular Function:
ionotropic glutamate receptor binding; protein binding
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Biological Process:
memory; positive regulation of long-term synaptic potentiation; regulation of AMPA glutamate receptor clustering; regulation of AMPA receptor activity; regulation of postsynaptic neurotransmitter receptor activity; regulation of short-term neuronal synaptic plasticity
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Reference #:
Q8C3Q5
(UniProtKB)
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Alt. Names/Synonyms: CKAMP; CKAMP59; cysteine-knot AMPAR-modulating protein 59; Cystine-knot AMPAR modulating protein of 59 kDa; D430041B17Rik; GABA(A) receptor auxiliary subunit Shisa7; Protein shisa-6-like; Protein shisa-7; Shisa family member 7; shisa homolog 7; shisa homolog 7 (Xenopus laevis); Shisa7; SHSA7
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Gene Symbols: Shisa7
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Molecular weight:
58,334 Da
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Basal Isoelectric point:
9.86
Predict pI for various phosphorylation states
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