SHISA7 Regulator of long-term synaptic potentiation specifically involved in the formation and retrieval of hippocampus-dependent contextual fear memory. Probably regulates induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses by affecting the recruitment of AMPA-type glutamate receptor (AMPAR) at postsynaptic density. Belongs to the shisa family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 7|7 A1
Cellular Component:  AMPA glutamate receptor complex; asymmetric, glutamatergic, excitatory synapse; cell junction; dendritic spine membrane; glutamatergic synapse; integral component of membrane; integral component of postsynaptic specialization membrane; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; synapse
Molecular Function:  ionotropic glutamate receptor binding; protein binding
Biological Process:  memory; positive regulation of long-term synaptic potentiation; regulation of AMPA glutamate receptor clustering; regulation of AMPA receptor activity; regulation of postsynaptic neurotransmitter receptor activity; regulation of short-term neuronal synaptic plasticity
Reference #:  Q8C3Q5 (UniProtKB)
Alt. Names/Synonyms: CKAMP; CKAMP59; cysteine-knot AMPAR-modulating protein 59; Cystine-knot AMPAR modulating protein of 59 kDa; D430041B17Rik; GABA(A) receptor auxiliary subunit Shisa7; Protein shisa-6-like; Protein shisa-7; Shisa family member 7; shisa homolog 7; shisa homolog 7 (Xenopus laevis); Shisa7; SHSA7
Gene Symbols: Shisa7
Molecular weight: 58,334 Da
Basal Isoelectric point: 9.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein