atlastin GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.-; Membrane protein, integral; Membrane protein, multi-pass; Vesicle
Chromosomal Location of Human Ortholog: 12|12 C2
Cellular Component:  cell projection; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network membrane; Golgi apparatus; Golgi cis cisterna; integral component of membrane; membrane
Molecular Function:  GTP binding; GTPase activity; hydrolase activity; identical protein binding; nucleotide binding; protein binding
Biological Process:  axonogenesis; endoplasmic reticulum organization; endoplasmic reticulum tubular network membrane organization; protein homooligomerization
Reference #:  Q8BH66 (UniProtKB)
Alt. Names/Synonyms: 4930435M24Rik; Adfsp; Atl1; ATLA1; atlastin GTPase 1; Atlastin-1; Fsp1; Spastic paraplegia 3A homolog; Spg3; Spg3a
Gene Symbols: Atl1
Molecular weight: 63,377 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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atlastin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene