AHCYL1 Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1. When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid. Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion. Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation. Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression. In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity. Belongs to the adenosylhomocysteinase family. Expressed in dendritic cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC; Hydrolase; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of mouse Ortholog: 3 F2.3|3 46.83 cM
Cellular Component:  apical plasma membrane; cytoplasm; cytosol; endoplasmic reticulum; intracellular membrane-bounded organelle; membrane; mitochondria-associated endoplasmic reticulum membrane; plasma membrane
Molecular Function:  adenosylhomocysteinase activity; identical protein binding; protein binding; RNA binding
Biological Process:  angiotensin-activated signaling pathway; apoptotic process; epithelial fluid transport; mitochondrion-endoplasmic reticulum membrane tethering; mRNA polyadenylation; one-carbon metabolic process; positive regulation of sodium ion transport; protein export from nucleus; regulation of anion transport; regulation of ion transmembrane transporter activity; regulation of mRNA 3'-end processing; response to calcium ion; S-adenosylmethionine cycle
Reference #:  Q80SW1 (UniProtKB)
Alt. Names/Synonyms: 1110034F20Rik; AA409031; AA414901; AdoHcyase 2; Ahcy-; Ahcy-rs3; Ahcyl1; DCAL; IP3R binding protein released with inositol 1,4,5-trisphosphate; IP3R-binding protein released with inositol 1,4,5-trisphosphate; Irbit; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase, related sequence 3; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1; SAHH2
Gene Symbols: Ahcyl1
Molecular weight: 58,951 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene