AHCYL1 an inositol 1,4,5-trisphosphate receptor 1 (IP3R1)-binding protein that inhibits IP3 binding to IP3R1 and IP3-induced intracellular Ca2 release. Suppresses the activation of IP3R1 via a phosphorylation-dependent mechanism. Also binds the Na/HCO3 cotransporter 1 (SLC4A4) and may play an important role in pH regulation. Contains a domain homologous to S-adenosylhomocysteine hydrolase (SAHH), although it is reported to possess no hydrolase activity. Its expression is induced in cultured monocytes when they are differentiated into dendritic cells (DC) by exposure to GM-CSF and IL-4. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of Human Ortholog: 3 F2.3|3 46.83 cM
Cellular Component:  apical plasma membrane; cytoplasm; cytosol; endoplasmic reticulum; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  identical protein binding; protein binding; RNA binding
Biological Process:  angiotensin-activated signaling pathway; epithelial fluid transport; mRNA polyadenylation; one-carbon metabolic process; positive regulation of sodium ion transport; protein export from nucleus; regulation of anion transport; regulation of ion transmembrane transporter activity; regulation of mRNA 3'-end processing; response to calcium ion; S-adenosylmethionine cycle
Reference #:  Q80SW1 (UniProtKB)
Alt. Names/Synonyms: 1110034F20Rik; AA409031; AA414901; AdoHcyase 2; Ahcy-rs3; Ahcyl1; DCAL; IP3R binding protein released with inositol 1,4,5-trisphosphate; IP3R-binding protein released with inositol 1,4,5-trisphosphate; Irbit; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase, related sequence 3; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1; SAHH2
Gene Symbols: Ahcyl1
Molecular weight: 58,951 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AHCYL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene