IDH3G
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Belongs to the isocitrate and isopropylmalate dehydrogenases family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.41; Mitochondrial; Oxidoreductase |
Chromosomal Location of mouse Ortholog: X A7.3|X 37.41 cM |
Cellular Component:
mitochondrial isocitrate dehydrogenase complex (NAD+); mitochondrion; nucleolus
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Molecular Function:
ATP binding; isocitrate dehydrogenase (NAD+) activity; magnesium ion binding; metal ion binding; NAD binding; nucleotide binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Biological Process:
2-oxoglutarate metabolic process; isocitrate metabolic process; NADH metabolic process; negative regulation of growth; tricarboxylic acid cycle
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Reference #:
P70404
(UniProtKB)
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Alt. Names/Synonyms: Idh3g; IDHG1; isocitrate dehydrogenase 3 (NAD+), gamma; Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma; OTTMUSP00000019257
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Gene Symbols: Idh3g
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Molecular weight:
42,785 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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