IDH3G Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Belongs to the isocitrate and isopropylmalate dehydrogenases family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.41; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: X A7.3|X 37.41 cM
Cellular Component:  mitochondrial isocitrate dehydrogenase complex (NAD+); mitochondrion; nucleolus
Molecular Function:  ATP binding; isocitrate dehydrogenase (NAD+) activity; magnesium ion binding; metal ion binding; NAD binding; nucleotide binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process:  2-oxoglutarate metabolic process; isocitrate metabolic process; NADH metabolic process; negative regulation of growth; tricarboxylic acid cycle
Reference #:  P70404 (UniProtKB)
Alt. Names/Synonyms: Idh3g; IDHG1; isocitrate dehydrogenase 3 (NAD+), gamma; Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma; OTTMUSP00000019257
Gene Symbols: Idh3g
Molecular weight: 42,785 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Select Structure to View Below

IDH3G

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein