MCT1 Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 3|3 F2.2
Cellular Component:  cell junction; centrosome; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; synapse
Molecular Function:  lactate transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; organic cyclic compound binding; protein homodimerization activity; symporter activity
Biological Process:  behavioral response to nutrient; cellular response to organic cyclic compound; centrosome cycle; glucose homeostasis; lactate transmembrane transport; lipid metabolic process; monocarboxylic acid transport; plasma membrane lactate transport; regulation of insulin secretion; response to food; transmembrane transport
Reference #:  P53986 (UniProtKB)
Alt. Names/Synonyms: AL022710; MCT 1; Mct1; Monocarboxylate transporter 1; MOT1; OTTMUSP00000025586; Slc16a1; solute carrier family 16 (monocarboxylic acid transporters), member 1; Solute carrier family 16 member 1
Gene Symbols: Slc16a1
Molecular weight: 53,267 Da
Basal Isoelectric point: 7.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene