|
MBP iso6
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Belongs to the myelin basic protein family. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal |
| Chromosomal Location of Human Ortholog: 18 E3|18 55.84 cM |
|
Cellular Component:
cell periphery; cell projection; compact myelin; cytoplasm; internode region of axon; membrane; myelin sheath; neuronal cell body; nucleus; plasma membrane; protein-containing complex
|
|
Molecular Function:
calmodulin binding; protease binding; structural constituent of myelin sheath
|
|
Biological Process:
maintenance of permeability of blood-brain barrier; MAPK cascade; membrane organization; myelination; negative regulation of heterotypic cell-cell adhesion; positive regulation of chemokine (C-C motif) ligand 2 secretion; positive regulation of interleukin-6 secretion; positive regulation of metalloendopeptidase activity; response to toxic substance; sensory perception of sound
|
|
Reference #:
P04370-6
(UniProtKB)
|
|
Alt. Names/Synonyms: C76307; goll; Golli-Mbp; Hmb; Hmbpr; jve; MBP; MBP iso6; mld; Myelin A1 protein; Myelin basic protein; myelin basic protein transcript variant X5; myelin deficient; OTTMUSP00000017514; OTTMUSP00000017515; R75289; Shi; shiverer
|
|
Gene Symbols: Mbp
|
|
Molecular weight:
17,225 Da
|
|
Basal Isoelectric point:
11.75
Predict pI for various phosphorylation states
|
