MBP iso6 The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Belongs to the myelin basic protein family. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 18 E3|18 55.84 cM
Cellular Component:  cell periphery; cell projection; compact myelin; cytoplasm; internode region of axon; membrane; myelin sheath; neuronal cell body; nucleus; plasma membrane; protein-containing complex
Molecular Function:  calmodulin binding; protease binding; structural constituent of myelin sheath
Biological Process:  maintenance of permeability of blood-brain barrier; MAPK cascade; membrane organization; myelination; negative regulation of heterotypic cell-cell adhesion; positive regulation of chemokine (C-C motif) ligand 2 secretion; positive regulation of interleukin-6 secretion; positive regulation of metalloendopeptidase activity; response to toxic substance; sensory perception of sound
Reference #:  P04370-6 (UniProtKB)
Alt. Names/Synonyms: C76307; goll; Golli-Mbp; Hmb; Hmbpr; jve; MBP; MBP iso6; mld; Myelin A1 protein; Myelin basic protein; myelin basic protein transcript variant X5; myelin deficient; OTTMUSP00000017514; OTTMUSP00000017515; R75289; Shi; shiverer
Gene Symbols: Mbp
Molecular weight: 17,225 Da
Basal Isoelectric point: 11.75  Predict pI for various phosphorylation states
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MBP iso6

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene