RCAN1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 11q11
Cellular Component:  cytoplasm; nucleus
Molecular Function:  calcium-dependent protein serine/threonine phosphatase regulator activity; identical protein binding; nucleic acid binding; protein phosphatase 2B binding
Biological Process:  calcineurin-NFAT signaling cascade; locomotion involved in locomotory behavior; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of smooth muscle cell differentiation; regulation of calcineurin-NFAT signaling cascade; regulation of phosphoprotein phosphatase activity; response to estrogen; response to ischemia; response to mechanical stimulus; response to oxidative stress; short-term memory; signal transduction; skeletal muscle fiber development; skeletal muscle tissue development
Reference #:  Q6IN33 (UniProtKB)
Alt. Names/Synonyms: Calcipressin-1; Down syndrome critical region gene 1; Down syndrome critical region homolog 1; Down syndrome critical region protein 1 homolog; Dscr1; MCIP1; Myocyte-enriched calcineurin-interacting protein 1; Rcan1; Regulator of calcineurin 1
Gene Symbols: Rcan1
Molecular weight: 22,948 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below

RCAN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene